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Alastair Dow
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Deprenyl: The Anti-Aging Drug Paperback – January 1, 1993

by Alastair Dow (Author)
4.4 4.4 out of 5 stars 11 ratings
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The disc overy of a new anti-aging drug, its health benefits,, and the long battle with the FDA to win approval.
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Previous page
  1. Print length
    268 pages
  2. Language
    English
  3. Publisher
    Hallberg Pub Corp
  4. Publication date
    January 1, 1993
  5. Dimensions
    5.5 x 0.75 x 8.5 inches
  6. ISBN-10
    087319036X
  7. ISBN-13
    978-0873190367
  8. See all details
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Editorial Reviews

From the Back Cover

"DEPRENYL is the first proven anti-aging, life extension drug. A discovery of major importance in preventive medicine." -Dr. Ronald Klatz

* "Deprenyl not only has anti-Parkinsonian properties, but may well be beneficial for treatment of Alzheimer's disease and certain protective/anti-aging properties." -Gwen Ivy, Ph.D.

* "L-Deprenyl is what good pharmaceuticals are all about. First, the agent is excepti nally safe. Secondly, it protects and enhances mental function, mood and even libido. Thirdly, it may extend life. Image -- a safe agent that enhances both the quality and leng th of life." -Dr. Juliam Whitaker

Product details

  • Publisher ‏ : ‎ Hallberg Pub Corp; First Edition (January 1, 1993)
  • Language ‏ : ‎ English
  • Paperback ‏ : ‎ 268 pages
  • ISBN-10 ‏ : ‎ 087319036X
  • ISBN-13 ‏ : ‎ 978-0873190367
  • Item Weight ‏ : ‎ 14.4 ounces
  • Dimensions ‏ : ‎ 5.5 x 0.75 x 8.5 inches
  • Customer Reviews:
    4.4 4.4 out of 5 stars 11 ratings

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Alastair Dow

Alastair Dow

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Customer reviews

4.4 out of 5 stars
4.4 out of 5
11 global ratings

Top reviews from the United States

D. A. Shinypenny
5.0 out of 5 stars Great book
Reviewed in the United States on July 10, 2018
Verified Purchase
Very informative and also helps explain why so many useful things never make it through the FDA.
4 people found this helpful
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Peter Uys
4.0 out of 5 stars The story of a miracle drug
Reviewed in the United States on March 8, 2005
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This is the story of the miracle medicine deprenyl (eldepryl), an inhibitor of the enzyme Monoamine Oxidase B. The book recounts how it was developed, the people that developed it and popularised it, the amazing benefits it provides to sufferers of Alzheimer's and Parkinson's disease, its preventive action against these, and its by now unquestioned role in extending lifespan.

In the Foreword, Saul Kent of the Life Extension Foundation takes a look at studies that confirm and extend the evidence of deprenyl's remarkable life extension benefits. He discusses its role in Alzheimer's disease, its mechanism of action, safety, boosting of anti-oxidant enzyme activity and how it extends lifespan.

The main body of the book tells the tale of Selegiline, Deprenyl or Eldepryl. It starts in the USA where instances are provided of how this medicine miraculously improved the lives of sufferers from Parkinson's disease.

Deprenyl is part of a group called the MAO Inhibitors. The first of these was Iproniazid, originally developed to treat tuberculosis, when it was discovered that it lifted the mood of sufferers from this disease. As a result, the MAO Inhibitors were used to treat depression, but they had severe side effects because of an interaction with certain foods like cheese.

In Budapest, Professor Joseph Knoll and Elizabeth Miller designed the molecule in 1961. Knoll kept it alive for 15 years until it went on sale in Hungary in 1978 as a treatment for Parkinson's. In 1971 Knoll argued that deprenyl does not have the side effects of the other MAOI's because it is a selective inhibitor of MAO. The article that finally opened the door to the worldwide use of deprenyl appeared in The Lancet in 1971.

A large part of the story is dedicated to the history of the trials and tribulations of getting deprenyl approved by the FDA for sale in the USA. This finally happened in June 1989 and only for Parkinson's.

The body's own most potent three internal free-radical scavengers are Glutathione Peroxidase, Superoxide Dismutase and Catalase. Subsequent studies have revealed that in addition to inhibiting Monoamine Oxidase B, deprenyl also strongly boosts the production of the anti-oxidant Superoxide Dismutase, and to a lesser extent, Catalase. In the foreword, Kent discusses the findings of several studies of this beneficial effect of deprenyl.

Appendix A is Case Studies by Dr Ronald Klatz of the American Longevity Research Institute. Appendix B consists of five abstracts: 3 Life Extension Studies by Dr Knoll, Dr Milgram and Dr Kitani, Deprenyl's Effect on Superoxide Dismutase and Catalase by Dr Kitani, and The Rescue Of Dying Neurons by Dr Tatton. Appendix C provides information on Alastair Dow, Dr Ronald M Klatz and Saul Kent.

The interested reader may also find Life Extension Magazine of value, plus the books The New-Anti Aging Revolution: Stopping The Clock by the aforementioned Dr Ronald Klatz, and Mind Boosters by Dr Ray Sahelian.
30 people found this helpful
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Michael Sinclair
3.0 out of 5 stars Not much clinical data
Reviewed in the United States on January 9, 2013
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This is mostly a group of stories about people who took this drug. Not much useful clinical information about the drug itself. For a patient, this book is fine. For a doctor, you won't learn much. No complaints about the seller.
2 people found this helpful
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Peter Hasbrouck
5.0 out of 5 stars Personal story
Reviewed in the United States on September 19, 2023
My father published this book and I just gave away a first edition. Who knew it has lasted this long on the Internet!
One person found this helpful
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A. Fazio
5.0 out of 5 stars Five Stars
Reviewed in the United States on November 29, 2016
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Amazing stuff!
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Jose Miguel Reyes Pulles
5.0 out of 5 stars Spread the word and you will be doing good to many people
Reviewed in the United States on December 8, 2014
What I have to say is that on September 20, 2014 i began taking selegiline for a starting Parkinson's my Neurologist diagnosed. In a few days I started to notice changes: a) The first thing was I have more drive to do the personal care duties like taking a bath, washing my teeth, etc. b) I was able to focus on intellectual tasks I had not being able to pursue for several years. c) The slight tremors I had on my head and hands diminished. e) My gait improved.

This was the book that moved me to ask my doctor about selegiline.

This is not a book for doctors, but I bet that no many doctors know about it. Just learning about its effects, uses and history is good for them and their patients. Then search the scientific literature if you wish.

If you want something directed to doctors, researchers, and medical students, please see:

 How Selegiline ((-)-Deprenyl) Slows Brain Aging

Also, remember that the human body is complex, and different approaches can complement one another. There are some issues in our mouths that can conduce our bodies to different degenerative diseases, Parkinson's among them. They can be treated. If you want to learn something about this, please see:

 Your Mouth is Key to Your Health: Focus on Your Teeth to Prevent, Cure or Alleviate Arthritis, Cancer, Cardiovascular, and other Chronic, Autoimmune, or Degenerative Diseases.
8 people found this helpful
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D.E.
3.0 out of 5 stars interesting book on an interesting drug
Reviewed in the United States on February 2, 2015
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interesting book on an interesting drug
2 people found this helpful
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Shelli Miller
5.0 out of 5 stars Interesting history and research in an easy-to-read format
Reviewed in the United States on August 21, 1999
My father has Parkinson's disease. This book gave me a lot of useful information about Deprenyl's progress through the years. It is written in an interesting format that draws your interest. I could relate to the book with symptoms and progression. It outlines the history-who and why-of Deprenyl and is detailed with case studies and testimonials. It even makes me think that I may explore taking Deprenyl myself when I am older for prevention of degenerative progress of aging. Read the book cover to cover--if you skip around many of the ironic and interesting details will be lost.
23 people found this helpful
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